2K noted in a developer Q&A, via GodisaGeek, that "there are no restrictions on what Superstars can compete in any match", though it is fully a player-made decision. They can incorporate both male and female Superstars, but if they'd prefer not to, that's fine, too. The only exception to the rule is mixed tag team matches, naturally.

WWE 2K25 has officially been unveiled with Roman Reigns on the cover and The Bloodline taking centre stage. Publisher 2K and developer Visual Concepts have promised something special this year, as they continue to revitalise the franchise and repair goodwill after relaunching with WWE 2K22 – following the disappointment of WWE 2K20.

One of WWE's top stars has teased that intergender wrestling matches might be included in WWE 2K25. The WWE 2K series has always heavily featured both its male and female stars. But WWE 2K25 might be taking things to another level by introducing a new feature: Intergender matches.