Nature

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients’ outcome

Prostate cancer (PCa) is the most frequently diagnosed tumor and the second largest cancer contributing to mortality in men. Its treatment depend on the stage of the disease, resulting in variable ...
Nature

Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma

Tumor-initiating cells are thought to share features with normal somatic stem cells. In mice, stem cells at the ovarian hilum have been shown to express the stem cell marker, aldehyde dehydrogenase ...
ascopubs.org

Expression levels of aldehyde dehydrogenase 1A1 (ALDH1A1) in circulating tumor and invasive cells (CTICs) as a biomarker for drug resistance and disulfiram in pancreatic ...

Identifying novel genetic alterations for risk stratification and prognostication in pancreatic cancer. Phase 1B trial of ADI-PEG 20 (A) plus nab-Paclitaxel (nab-P) and gemcitabine (gem) in subjects ...
BioWorld

New inhibitors of ALDH1A1, 2 and 3 disclosed in Theranib patent

Theranib Inc. has divulged retinal dehydrogenase 1 (ALDH1A1; RALDH1) and/or retinal dehydrogenase 2 (ALDH1A2; RALDH2) and/or aldehyde dehydrogenase family 1 member A3 (ALDH1A3; RALDH3) inhibitors ...