Preclinical model systems are invaluable tools for drug discovery and development. But many complex diseases, such as nonalcoholic steatohepatitis (NASH), are difficult to recapitulate in the ...

The design of a two-color microarray experiment can be considered as having three layers. Figure 1 shows an example of an experiment that compares the effects of two treatments—A and B—on ...

Sound experimental design is of vital importance when conducting any scientific experiment. Choices made at the design stage have the potential to drastically impact the results of any study. A strong ...

We have already seen that varying two factors simultaneously provides an effective experimental design for exploring the main (average) effects and interactions of the factors 1. However, in practice, ...