Bottom Line: Potassium channels play an important role in controlling the electrical activity of neurons in the brain. We identified and characterized a new compound, called GiGA1, that selectively ...
Bottom Line: Potassium channels play an important role in controlling the electrical activity of neurons in the brain. We identified and characterized a new compound, called GiGA1, that selectively ...
A group from The Mount Sinai Hospital / Mount Sinai School of Medicine have identified and characterized a novel a GIRK1-selective activator, GiGA1 capable of selectively opening a subset of G-protein ...
Hablitz, LM, Molzof, H., Abrahamsson, KE, Cooper, JM, Prosser, RA and Gamble, KL (2015). GIRK channels mediate the nonphotic effects of exogenous melatonin. J ...
Researchers from Columbia University Irving Medical Center published data from a study that assessed GiGA1, a selective G protein-gated inwardly rectifying potassium channel (GIRK) activator, in ...
G protein-coupled receptors (GPCRs) constitute one of the largest families of membrane proteins and play a pivotal role in translating extracellular signals into diverse intracellular responses. A key ...
Figure 1: Ethanol potentiates a potassium current induced by rapid activation of GABA B receptors in cerebellar granule cells in culture. The alternative text for this image may have been generated ...
A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where ...
The neurological disease epilepsy afflicts about 50 million people worldwide and is difficult to treat. Current treatments leave around 30% of patients with inadequate control of their seizures, ...
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