The global burden of tuberculosis (TB) remains high, with millions of new infections and deaths each year. Early and accurate distinction between latent infection and active disease is crucial for ...

Interferons are type of protein called a cytokine. They have important roles in the immune system. Interferons are split into three distinct families – Type I, Type II, and Type III. Due to their role ...

Previous research using animal models has indicated the importance of T‐cells, particularly CD4+ and CD8+ T-cells, in protecting individuals against the severe acute respiratory syndrome coronavirus 2 ...

This is the second World TB Day and the end of the first full year since the world encountered COVID-19. We have all worked feverishly to manage this pandemic and its consequences. What impact has ...

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine and the sole member of the type II interferon class. Originally referred to as macrophage-activating factor, IFN-γ is now recognized as ...

Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic ...

Researchers have discovered that the interferon gamma receptor (IFNgR) signaling pathway is critical for susceptibility of glioblastoma tumors to killing by CAR T-cell immunotherapy. Researchers at ...