The conserved co-activator complex Mediator enables regulated transcription initiation by RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) comprising all ...
Design patterns are used to solve common design problems and reduce the complexities in our code. The mediator pattern is a behavioral design pattern that promotes loose coupling between objects and ...
A basic function of the Mediator complex is to communicate regulatory signals from DNA-binding transcription factors (TFs) directly to RNA polymerase II (Pol II). Different TFs, and the signalling ...
Take advantage of MediatR and the mediator design pattern to reduce the dependencies between objects in your ASP.Net Core applications MediatR is an open source project and an implementation of the ...
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