A new study, led by Professors Mashaghi and Clevers from Leiden University and Hubrecht Institute in the Netherlands, has introduced a novel approach using intestinal organoids to uncover the ...

Attrition in the therapeutic pipeline can typically result from a lack of translational efficacy between the pre-clinical phase and the clinic. Organoids offer much promise in drug screening and ...

Organoids are three-dimensional, miniaturized, and simplified versions of organs produced in vitro from stem cells or organ-specific progenitor cells. They recapitulate key structural and functional ...

Tuft cells are present throughout the intestinal tract as well as in many organs. Studies in mice have shown that when tuft cells sense the presence of pathogens, they signal to immune cells and to ...

In a recent study, FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Molecular Devices UK Ltd offers 3D Ready ™ Organoids in cryopreserved vials, an "off-the-shelf" solution for researchers looking to use physiologically appropriate, patient-derived organoid models ...

Plastics pervade every aspect of the human life, being present in packaging and household goods, agricultural, food and medical products. Their resistance to (bio)degradation has resulted in the ...