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'ALS on a chip' model reveals altered motor neuron signaling

Using stem cells from patients with ALS (amyotrophic lateral sclerosis), Cedars-Sinai has created a lifelike model of the mysterious and fatal disease that could help identify a cause of the illness ...
GEN

ALS Resource Examines Gene Expression in Patient Stem Cell Derived Motor Neurons

Results of a largescale collaborative project led by scientists at the Cedars-Sinai Medical Center, Los Angeles, and the University of California, Irvine (UCI), were published in the journal Neuron ...
EurekAlert!

Common genetic causes across motor neuron diseases identified

(MEMPHIS, Tenn. – October 29, 2025) Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical similarities but have been largely viewed ...
The Scientist

Why Do Motor Neurons Die First in ALS? Turns Out, Size Matters

Motor neurons are some of the largest cells in the human body. In particular, upper neurons—extending from the cerebral cortex to the brain stem or spinal cord—average 60μm in diameter. 3,4 These ...