APL is a distinct subtype of myeloid leukaemia that in almost 100% of cases is associated with chromosomal translocations involving the PML and retinoic acid receptor α (RARA) loci, leading to the ...

Telomeres interact with numerous proteins, including components of the shelterin complex, whose alteration, similarly to proliferation-induced telomere shortening, initiates cellular senescence. In ...

The country’s two biggest opposition parties – the PML-N and the PPP – have criticized the National Accountability Bureau (NAB) for seeking access to local and offshore tax records and opposed any ...

New findings define a pathway that maintains PTEN in the nucleus and offer a novel target for enhancing this gene's tumor suppressive function. The PTEN tumor suppressor gene controls numerous ...

Progressive multifocal leukoencephalopathy (PML) occurring with ocrelizumab (Ocrevus) monotherapy developed in a 78-year-old man with progressive multiple sclerosis (MS), the first such case known, ...