Cell-surface proteins are critical therapeutic targets and are vital to cellular communication, signaling, and homeostasis. However, developing high-affinity probes such as aptamers against these ...

The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

Creating analytical tools that support the advancement of knowledge can often come about through the integration of existing information and techniques, theoretical and practical, directed toward a ...

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a ...

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

A new artificial intelligence model can predict how different proteins may bind to DNA. A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how ...

Recently, SandboxAQ launched what it claims is the largest publicly available dataset of protein-ligand pairs with annotated experimental binding potency data. According to the company, the ...

This article is based on a poster originally authored by Dillon Rinauro, Thomas Peplow, Phil Rawlins, Alec O'Keeffe, Corinne Tovey, Tayo Alleyne-Weir, James Craswell, Kartika Shetty, Michaela ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...