Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

Even those who doubt the RNA World hypothesis may be hard-pressed to argue against it. Consider the predicament faced by a team of scientists at Scripps Research. They suspected that RNA was a poor ...

Researchers have developed a customizable, RNA-based platform to target cells rather than genes. CellREADR enables scientists to add any protein to a designated cell type. Initial evidence ...

These structures are involved in the regulation of gene expression, where the double-stranded regions typically carry specific functions and, if lost, may cause severe disorders. A double-stranded ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Researchers in China have developed a new method that allows them to insert long stretches of DNA into a genome. The process, named GRAND editing, is one of a handful of new systems aimed at using two ...

Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA.