The orbitofrontal cortex (OFC), a subsection of the brain's frontal lobe, is known to play a part in value-based decision-making, the process of mentally weighing the outcome of different decisions ...

New research published in JCCP Advances indicates that experiencing negative life events (NLE) during childhood is linked with a higher risk of developing symptoms of depression during young adulthood ...

Life can be tricky. We have so many decisions to make. It's a good thing we have an orbitofrontal cortex and hippocampus to help us. These areas of the brain work together to help us sort through ...

Depression imposes a major global socioeconomic burden, and current pharmacotherapies face several limitations, including slow efficacy, adverse effects, and non-response rates of up to 55%, ...

Newly identified brain cells evolved along the theme, "Life is uncertain; Eat dessert first." The neurons, located in the front part of the brain, are most active when the outcome of a decision is ...

Overexpression of Shisa7 in the orbitofrontal cortex in drug-free rats induced comparable up and down changes in gene expression as that induced by the self-administration of heroin. The concordant ...