Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

It has long been accepted that a gene's protein-coding information is contained in only one of its two DNA strands. But in 22 February Nature, Victor Corces and co-workers at the Department of Biology ...

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes ...

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

Researchers have created the most comprehensive map to date of DNA elements that regulate gene activity, nearly tripling the ...