eLife5h
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
The compelling evidence explains how Rab8 family members bind at two sites to allosterically regulate MICAL1, and relieve an auto-inhibited state unable to bind actin. This study lays the basis for ...
eLife6h
Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors
Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...
eLife6h
Introduction of cytosine-5 DNA methylation sensitizes cells to oxidative damage
This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...
eLife6h
TET2 contributes to gluconeogenesis and pathology of type 2 diabetes
Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ...
eLife1d
Colony demographics shape nest construction in ants
This study presents an important finding that ant nest structure and digging behavior depend on ant age demographics for a ground-dwelling ant species (Camponotus fellah). By asking whether ants ...
eLife2d
Oxytocin salvages context-specific hyperaltruistic preference through moral framing
This study presents a valuable finding that altruistic tendency during moral decision-making is context-dependent (present in the gain domain but absent in the loss domain) and its absence in the loss ...
eLife2d
Science Communication: Tips for promoting your research
Effectively communicating your research can help to maximise its impact in your field and communities. We share some advice on how to broaden the reach of your findings, and ensure that your message ...
eLife2d
Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...
eLife2d
Neuronal Development: Rethinking sensorimotor circuits
New research shows that the neural circuit responsible for stabilising gaze can develop in the absence of motor neurons, contrary to a long-standing model in the field.
eLife3d
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
This valuable study examines how different exercise training intensities affect intestinal barrier function and gut microbiota composition over a 6-week period in mice. The evidence supporting the ...
eLife3d
Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...
eLife3d
Computational method pinpoints how cause-and-effect relationships ebb and flow over time
A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.