May 1, 2025 · A robust scale-down model development and process characterization for monoclonal antibody biomanufacturing using multivariate data analysis

Jul 12, 2024 · Monoclonal antibodies (mAbs) used in biomedical research and therapeutic applications are primarily produced by Chinese hamster ovary (CHO) cells via fed-batch …

In the antibody biomanufacturing process, antibodies are produced through expression in living cells, such as CHO cells. Genetic material from the cells, known as residual host cell DNA, is a …

The perfusion medium is critical in maintaining high cell concentration in cultures for the production of monoclonal antibody by Chinese hamster ovary cells. In this study, the effects of …

Nov 18, 2024 · 2.3 Perfusion Culture of CHO Cells to Generate Spent Media To generate spent media for regeneration and culture experiments, a 500 mL bioreactor (Getinge Applikon) was …

Jul 15, 2024 · Yes, as many of your listeners may know, antibody therapeutics typically achieve high titers and productivity in mammalian cell cultures. By implementing perfusion cell culture, …

As a resource for future projects, upstream process levers for controlling afucosylation were summarized, which can be used for effective control of afucosylation levels from early to late …

Dec 5, 2023 · The addition of nutrients and accumulation of metabolites in a fed-batch culture of Chinese hamster ovary (CHO) cells leads to an increase in extracellular osmolality in late …

Abstract The WuXi Biologics' Ultra-high Productivity platform (WuXiUP) technology is an innovative and integrated platform of continuous biomanufacturing. Through process …

Process Development and Manufacturing Monoclonal antibodies (mAbs) are manufactured using a templated approach requiring robust, scalable, and regulatory compliant technologies to …