The ultimate Mississippi cruise - traversing the entire length of the river - stopping at all of the most iconic ports in the region, including New Orleans, Memphis, Hannibal, Winona, and more.

Feb 16, 2025 · The company’s Mississippi offerings range from 8 to 51 days and include an array of authentic American experiences in 10 states from New Orleans, Louisiana to St. Paul, Minnesota.

Oct 7, 2025 · The largest river cruise line in the U.S., American Cruise Lines offers 28 small ships sailing the Mississippi River, the Columbia and Snake rivers and protected waterways all over the country.

Jun 12, 2025 · We’ve rounded up the best Mississippi River cruises for seniors, history buffs and Americana lovers, so you can find your perfect U.S. river cruise itinerary based on your interests and …

Dec 9, 2024 · These stylish riverboats with more comfort and many unique amenities are quickly replacing the paddlewheelers but American Cruise Lines still has four of these nostalgic vessels …

Sep 22, 2025 · American Cruise Lines has announced that it is adding capacity and itineraries on the Mississippi River and tributaries by introducing the first-ever nine-day “Arkansas River” cruise …

Aug 16, 2025 · Sail the Lower Mississippi from Memphis to New Orleans with American Cruise Lines Mississippi River cruise, exploring historic towns, plantations, and vibrant Southern culture.

Cruise the Mighty Mississippi with American Cruise Lines. Travel on the Mississippi aboard elegant new riverboats, where you will be transported back in time to an era of leisurely and romantic travel.

Cruise the entire length of the Mississippi River- from New Orleans to St. Paul. Explore the beauty, history, and culture. Book your adventure today.