Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Jan 1, 2017 · Figure 1: Simulated chromatograms for a mixture of six neutral compounds (unlabeled peaks between approximately 3 and 9 min) and two carboxylic acids at (a) pH 7.0 and (b) pH 3.0. The peak at approximately 0.75 min is t 0.. When ionizable analytes are present, dramatic changes in retention can take place when the mobile-phase pH is altered.

Jan 1, 2019 · Founded in 1983, LCGC International is the leading provider of digital and print content to the separation science market, enhancing the productivity, efficiency, and the overall value of separation techniques globally. With our commitment to editorial excellence, we have pioneered innovation across a broad portfolio of digital and print platforms.

LCGC International spoke to Michelle Klein from the Faculty of Chemistry of the University of Duisburg-Essen (Essen, Germany) about how, by using the green analytical chemistry tool Analytical GREEnness (AGREE) and the white analytical chemistry (WAC) framework, her team was able to conduct a comparative analysis of gas chromatography-tandem mass spectrometry (GC–MS/MS), liquid ...

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Aug 1, 2018 · Douglas E. Raynie "Sample Prep Perspectives" editor Douglas E. Raynie is a Department Head and Associate Professor at South Dakota State University. His research interests include green chemistry, alternative solvents, sample preparation, high-resolution chromatography, and bioprocessing in supercritical fluids.

Dec 26, 2024 · Gas chromatography (GC) is a cornerstone of analytical chemistry, known for its versatility. At LCGC International, we have actively covered developments in GC through our technical articles, news coverage, conference reports, and interviews with both emerging talents and seasoned experts.

Jun 10, 2024 · Case Studies from an Early-Phase Small-Molecule Development Project: Background Information. A case study from my experience as a chemistry, manufacturing, and controls (CMC) analytical team lead supporting an early-phase small-molecule oncology drug development project was used to illustrate how CoAs expedite quality documentation of testing methods and results.

Oct 1, 2012 · An overview of the principles and equipment required for scaling analytical separations to the preparative scale and considerations for the scale of analyte required.

Jul 1, 2019 · The invention of the electron capture detector (ECD) is attributed to Lovelock in 1957 (1). The detector measures the electrical conductivity of an effluent gas stream resulting from exposure to ionizing radiation from a radionuclide.